Title: 1563 - Association of Peripheral Arterial Disease and Periodontitis – A Retrospective Analysis of Health Insurance Claims Data


Ghazal Aarabi (Presenter)
Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf

Udo Seedorf, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf
Guido Heydecke, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf
Christian-Alexander Behrendt, University Heart Center Hamburg, University Medical Center Hamburg-Eppendorf


Objectives: Background: Limited information exists on the association between periodontitis (PD) and peripheral arterial disease (PAD).

Methods: Patients and methods: The association between PD and PAD was examined by analysing health insurance claims data of people insured with the German health insurer BARMER between 2012 and 2015. The presence of PAD was established in individuals with adequate ICD-10 GM codes for intermittent claudication (IC) or chronic limb-threatening ischaemia (CLTI). Presence of PD was assessed by adequate ambulatory codings for non-surgical and surgical treatment of moderate or severe PD.

Results: Results: Among 13,860,549 hospitalized adults of both sexes, the study cohort included 52,510 hospitalized patients with a diagnosis of PAD (men: 54.2%; women: 45.8%). The highest proportion of PAD cases was classified in CLTI (54.5%), followed by stages IC (45.0%) and “asymptomatic” (0.05%). The cohort included 2,254 (4.3%) patients with at least one PD related code, indicating presence of and treatment for PD (men: 4.6%, women: 3.9%), mostly by non-surgical therapies (96.0%). PAD patients who had received PD treatment of any kind showed a significantly decreased proportion of clinically severe PAD forms (CLTI: 32.9% treated vs. 55.4% non-treated) and a relative increase of clinically more benign PAD forms (asymtomatic & IC: 67.1% treated vs. 44.6% non-treated). The odds ratio (OR) for CLTI, treated vs. untreated was 0.39, 95% confidence interval (CI): 0.36 - 0.43 (men: OR 0.45, 95%CI 0.40 - 0.50; women: OR 0.33, 95%CI 0.29 – 0.38).

Conclusions: Conclusion: In this retrospective analysis of a large health insurance claims data set of hospitalized PAD patients, PD treatment of any kind was associated with a shift of clinically severe PAD forms (chronic limb-threatening ischemia, CLTI) to less severe PAD forms (asymptomatic or intermittent claudication, IC).

This abstract is based on research that was funded entirely or partially by an outside source:
This work was funded by the German Federal Joint Committee (Gemeinsamer Bundesausschuss, Funding No. 01VSF16008)

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE